IGF-1 LR3 – Europe Pharmaceutical, 1 mg

Insulin-Like Growth Factor-1, commonly referred to as IGF-1 is a polypeptide hormone that belongs to the growth factor hormone family. This is a naturally produced hormone in all human beings with production primarily occurring in the liver, and to a degree in the peripheral tissues. However, synthetic versions do exist and are produced by recombinant DNA technology.

IGF-1 is a highly anabolic hormone that affects numerous areas of the human body. It also shares an important relationship with Human Growth Hormone (HGH), and on a structural basis is similar to insulin. There are several synthetic IGF-1 products on the market, but perhaps the most well-known is Increlex manufactured by Tercia INC.

In a therapeutic setting IGF-1 is primarily used to treat IGF-1 deficiencies. However, it is also used in patients who do not respond to HGH. With this type of therapy, the individual may very well have plenty of HGH in his system but for one reason or another is not responding to the hormone. IGF-1 treatment for this purpose is FDA approved, but it is considered very controversial by some medical professionals due to the possible metabolic effects that could occur. Then we have performance enhancement, and in recent years IGF-1 has become an important hormone in this arena. It is powerfully anabolic, will carry strong recovery properties and has become a favorite of many in bodybuilding circles.

IGF-1 is a protein hormone comprised of a string of 70 amino acids. Synthetic or naturally produced the sequence is the same; there is no difference. As a functioning hormone, IGF-1 largely functions by supporting growth through the enhancement of amino acids, glucose and fatty acids. As it shares a close relationship with insulin, it can also affect your blood sugar levels. The use of IGF-1 can potentially lower your blood sugar significantly resulting in a hypoglycemic state. Due to the enhancement of fatty acids, this further creates the ability to promote body fat, which is definitely a potential downside to use. However, the upside can make it worthwhile if a well-planned diet and lifestyle is in place when supplementing with exogenous IGF-1.

IGF-1 has been shown to greatly increase the number of cells in the skeletal muscle, which in turn can lead to an enhancement in lean tissue growth. This occurs by activating the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. Not only can it promote muscle growth, but by this mode of action it can also promote bone growth, and to a degree growth of our internal organs.

IGF-1 also shares a close relationship to HGH, another powerful and naturally produced hormone by all human beings. HGH, like IGF-1, is anabolic and IGF-1 is largely responsible for a large portion of the anabolic action provided by HGH. This includes two primary traits that are commonly associated with anabolism in nitrogen retention and protein synthesis. Enhanced nitrogen retention is important due to the fact that all lean tissue is comprised of approximately 16% nitrogen. When nitrogen stores fall, this can send the individual into a catabolic (muscle wasting) state. Conversely, the more nitrogen we retain the more anabolic we remain; we build and support more lean tissue. As for protein synthesis, this represents the rate by which cells build proteins, proteins representing the primary building block of lean muscle tissue. It’s not too hard to see how an enhancement in protein synthesis would be beneficial. This will not only allow you to build and support more lean tissue, but will play an integral role in the recovery process, which is precisely where true progress is made. This closely tied relationship between IGF-1 and HGH is also what leads to increases in muscle cells and the promotion of new muscle fiber growth. With IGF-1 you will now have more muscle cells (muscle cell hyperplasia) and muscle fibers (mitogenesis) to work with.

While the functions and traits of IGF-1 in an anabolic capacity are tremendous, they are ruled by the amount of protein supplied to the muscle cells. Without adequate amounts of protein, exogenous IGF-1 supplementation will be worth very little.

IGF-1 also carries important traits revolving around healing and recovery; in fact, they are quite strong. This is very apparent when we consider the hormone’s role on the production of connective tissue. IGF-1 will also improve collagen function, collagen, which is found in all connective tissue in the body. An improvement in collagen function results in stronger bones, as well as strength in the muscles for proper movement. It can even affect the skin and blood vessels in a positive way. From here, IGF-1 will also promote cartilage repair and promote enhanced bone density making it an excellent hormone in cases of needed rejuvenation and repair.

A final note on the traits of IGF-1: this hormone is known as a neuroprotector and neuropromotor, which could potentially lead to improved mental function. This factor could potentially be very beneficial to the elderly when issues of dementia arise. However, further study is still required in order to fully understand the effects, but they do appear to be promising.

The effects of IGF-1 are normally best suited for promoting off-season mass and for the physical recovery of any athlete. Very few will use this hormone in a cutting cycle, as it can have a negative effect on the individual’s metabolic rate. That’s the last thing you want when dieting, but we can make an exception. Some competitive bodybuilders are able to use IGF-1 during their contest prep and stay lean, while also maintaining more of their lean mass. It takes years of experience to be able to pull this off and not only a thorough understanding of hormones but a thorough understanding of how they affect you as an individual.

For the individual looking for raw size, there are a couple of solid options when considering IGF-1 use. Many will use it during their course of anabolic steroids, which will only enhance the rate in which lean tissue is built, as well as the amount. Others, and this is typically for more advanced bodybuilders, will use it during a bridge period. A bridge refers to a period of time in-between anabolic steroid cycles or full blown cycles. In this case, the individual will continue using a maintenance dose of testosterone and add in the IGF-1. Many who do this are also using HGH and simply continue it from their cycle that just ended into the bridge that just began. Regardless of your specific time of use, during cycle or as a bridge, the use of HGH is normally advised. IGF-1, while powerfully anabolic also has the ability to promote excess fat storage. During an off-season bulking stage, maintaining proper body fat levels is hard enough on its own, and it’s only complicated by the use of IGF-1. However, when we include HGH the metabolic boost it provides should be enough to keep things under control. Further, the synergy between these two hormones is remarkable.

What can you expect out of IGF-1 during off-season use? It’s hard to put a specific number on the amount of weight gained or specific increases in strength. As every human being is different and responds a little differently this can be hard to determine. However, we do have data to pull from, specifically a study done on IGF-1 using mice. In the study, the mice given IGF-1 a 15% increase in mass and a 14% increase in strength. Those may sound like small numbers to you, but that’s truly a remarkable increase. For example, take a 220lb bodybuilder, if his mass increases by 15% he now weighs 250lbs and that’s hardly a small increase. Of course, data obtained using mice, while often a good indicator is not always accurate. A prime example of inaccuracy would be the studies that showed strong anabolic action with the bronchodilator Clenbuterol, but when used in humans the anabolic action didn’t translate. However, while we cannot say with certainty a human being will experience a 15% increase in mass, we do know the anabolic power of IGF-1 in humans is extremely strong. Even if it’s only half of what was reported in mice that’s still a dramatic improvement.

The final effects of IGF-1 surround recovery. The hormone will improve overall recovery from training and strenuous activity, but it doesn’t end there. IGF-1 actually carries direct healing properties, not masking like a painkiller but true therapeutic healing. The use of IGF-1 can greatly reduce the total time for healing joint injuries. It has even been shown to significantly aid in the healing of tendons and ligaments. As all these areas of the body take a beating by most athletes, IGF-1 becomes extremely valuable.

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